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IGF1R deficiency depletes peripheral monocytes, bone marrow neutrophils and leukocyte counts in BALF, and attenuates the increase of serum IL6 and TNF levels after experimental pulmonary metastasis To determine the effect of IGF1R deficiency on key components of the lung TME, we performed an experimental pulmonary metastasis model

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

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Maintain sterile handling techniques throughout the study