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It did both of these things while crossing the blood-brain barrier and maintaining a plasma half-life exceeding 6 hours, which means sustained brain exposure from a single administration

Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal [lower than normal], further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly

It has not received FDA approval for therapeutic use in humans

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This is why AOD-9604 works synergistically with low-glycemic eating patterns