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Metabolic parametersincluding insulin resistance, lipid profiles, and gut microbiome alterationsplay a significant role in NAFLD pathogenesis and could provide a broader understanding of GSHs systemic effects

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For example, formaldehyde dehydrogenase uses NAD + to catalyze the oxidation of an adduct of formaldehyde and glutathione to produce S-formylglutathione, which is subsequently hydrolyzed by a specific lyase to yield formate and regenerate the glutathione