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Most community protocols start cagrilintide at 0.25 mg/week once tirzepatide is established, then step up every 4 weeks to 0.5, 1.0, 1.7, and 2.4 mg/week

Systemic NETosis and thromboinflammatory propagation NETs constitute a structural and biochemical bridge between innate immunity and the coagulation system: the DNAhistone backbone and associated neutrophil proteins act as both a physical scaffold and as a biochemical activator that concentrates platelets, fibrinogen, von Willebrand factor, and coagulation enzymes at sites of inflammation [61, 62]

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Its especially relevant for those with borderline or low GH levels, often confirmed via bloodwork (e.g., IGF-1 testing)