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Tau oligomers bind to cardiolipin, and this binding leads to the creation of membrane pores, causing mitochondrial swelling, cytochrome c release, and a reduction in membrane potential ( Figure 5 illustrates schematically the processes that eventually lead to Alzheimers disease, where the major players are Abeta, phosphorylated tau, and cardiolipin

Konoplev S, Kornblau SM, Schlette E, Lu H, Thomas DA, Zhang N, Qiu YH, Coombes K, Neeley S, Kantarjian HM, Medeiros LJ, Andreeff M , Konopleva M

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