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However in our opinion, the low probability of MS coincidence with another rare disease, together with the animal studies where MS is never a consideration, makes it more likely that these human examples align with an inside-out model (Figure 2), where a primary biochemical derangement of myelin, coupled with an immune predisposition, culminated in a MS-like phenotype

These are known as "free radicals"

Activation of the HPA axis during the training greatly increases the cortisol levels (112), which acts as a metabolic and catabolic hormone (113) by mobilizing the glucose (114), endogenous stores of amino acids (115), and fatty acids (116), enhances the availability of all fuel substrates

Additional information How to cite this article: Jiang, X

J Physiol Pharmacol 2003