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Moreover, aged garlic extract was shown to normalize NO output from endothelial cells by preventing the decline of BH4 levels

However, futile quinone redox cycling can lead to a cascade of ROS formation and as such, the link between toxicity and quinone redox cycling is widely acknowledged 5

Kimonis VE, Troendle J, Rose SR, Yang ML, Markello TC, Gahl WA (1995) Effects of early cysteamine therapy on thyroid function and growth in nephropathic cystinosis

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Despite a promising in vitro antitumor activity, the development of this therapy faced off serious side effects, limiting its potential development as anticancer therapy