The gut microbiome is integral to the development and functioning of the HPA axis, which regulates neuroendocrine responses and manages stress [149]
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Later, PTPN22, located on 1p13, is the last immunoregulatory gene identified in the disease
Methodologies for Studying IBS and Associated Microbiome In this section, we review several methodologies available for studying IBS, including the establishment of animal models, and in vitro models with the latest innovations of gut-on-a-chip systems