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Beyond sleep, DSIP has demonstrated a remarkably broad research profile: it modulates the HPA stress axis by reducing basal cortisol and ACTH levels, enhances endogenous opioid signalling to raise pain thresholds without tolerance development, and upregulates antioxidant defence enzymes including SOD, catalase, and glutathione peroxidase

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Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation

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KLOW adds KPV as an anti-inflammatory fourth peptide