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These data collectively suggest that the inhibitory effect of GSSG on the NF-B signaling pathway, via suppression of IKK- activation, is mechanistically implicated in the increased sensitivity of hepatocytes to TNF killing

suggest that GHK-Cu may also tone down inflammatory signaling in macrophages activated by pro-inflammatory triggers and in lung cell injury models

& Roychoudhury, A

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Future progress will require: (1) Parameter optimization studies: Systematic in vitro screening of DECLARATIONS Authors contribution Writing - original draft, investigation, conceptualization, and funding acquisition: Wang LY Writing - review and editing: Fan MY, Jiang XY, Bing KJ, Wang YJ, Zhang H Writing - review and editing, supervision: Wang KS, Huang YM Availability of data and materials Not applicable