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Grieco A, Miele L, Forgione A, Ragazzoni E, Vecchio FM, Gasbarrini G

Mouse-model results should not be assumed to predict human outcomes at any dose or by any route

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In addition, Shewanella algae K3259 naturally synthesizes tetrodotoxin (TTX), a compound with known antitumor activity, but its low in situ production limits therapeutic efficacy

A variety of natural and synthetic compounds have been identified as activators, and some of their mechanisms of action have been partially elucidated