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doi: 10.1056/NEJMoa1012985 196

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The MCCC2 gene is located on chromosome 5q13.2 and is composed of 19 exons that generate two alternatively spliced mRNAs that encode precursor proteins of 563 and 525 amino acids

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Estrogen suppresses this process indirectly by stimulating osteoblasts to produce osteoprotegerin (OPG), a soluble decoy receptor that binds RANKL and prevents its interaction with RANK

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