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The activity of Mfn2 is also regulated by signal transducer molecule 2 (recombinant mothers against decapentaplegic homolog 2, Smad2), which acts as a scaffold to recruit Rab-Ras interacting factor 1 (RIN1) to form the Smad2-RIN1-Mfn2 complex with Mfn2, which ultimately promotes ATP synthesis and mitochondrial fusion (Kumar et al., 2016)
A 2025 narrative review in Current Reviews in Musculoskeletal Medicine identified only three published human studies: Lee & Padgett (2021) on knee pain (n=16), Lee et al
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PMID: 62 TakkarSSharmaGKaushalJBAbdullahKMBatraSKSiddiquiJA
Validity and reliability of the International Cooperative Ataxia Rating Scale (ICARS) and the Scale for the Assessment and Rating of Ataxia (SARA) in multiple sclerosis patients with ataxia
