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Higher levels mean those junctions are opening up

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs

10.1002/mrdd.1039 Ment

A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published

Finally, a large proportion of the other studies reviewed herein, including the ones focused on exercise, did not include or report on mitochondrial readouts following NAD + modulation