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First, Graf and Kastin (1984) [4] describe a U-shaped activity curve for both dose and infusion duration, meaning there are optimal windows of effect rather than a monotonic dose-response relationship

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Clinical trials examining GHK-Cu effects on facial hyperpigmentation have reported variable results, with some studies documenting 15-30% reductions in melanin index measurements over 8-12 week treatment periods, while others report minimal pigment-lightening effects