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Frequency depends on your needs and provider recommendations

Place the pen base flat against your skin as directed in the Instructions for Use, choose injection sites with adequate subcutaneous fat (abdomen, thigh, or upper arm), and rotate sites weekly

In the context of brain function, these may provide protection from neurodegenerative processes

Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition