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Another small, randomized, double-blind trial in 93 individuals with low vitamin D status found no additional benefit of B-vitamin supplementation (50 mg/day of vitamin B6, 0.5 mg/day of folic acid, and 0.5 mg/day of vitamin B 12 ) on markers of bone health over a one-year period beyond that associated with vitamin D and calcium supplementation

GI side effects common during titration

The exact amount depends on the patients health, how bad the deficiency is, and the doctors advice

Cyanocobalamin is popular and effective, but hydroxocobalamin might offer unique benefits