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showed that during AD onset phase, patients had reduced circulating levels of melatonin and beta-endorphin, despite higher nocturnal levels of both hormones

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The antioxidants involved in the second phase are regulated by transcriptional master Nrf2/Keap1 (nuclear factor erythroid-2 related factor 2/Kelch Like ECH Associated Protein 1)

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10.1038/nm.3400 Nat

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