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Unlike injectable versions that enter circulation directly, oral capsules rely on advanced delivery systems to maintain efficacy

Key Highlights from REIMAGINE 13 REIMAGINE 1 (Diet & Exercise Alone) 40 Weeks HbA1c reduction: 1.8% Weight loss: 13.8% Baseline HbA1c: 7.8% REIMAGINE 2 (Metformin SGLT2 Inhibitor) 68 Weeks HbA1c reduction: 1.91% Weight loss: 14.2% Demonstrated superiority over semaglutide 2.4 mg: * HbA1c: 1.91% vs 1.75% * Weight loss: 14.2% vs 10.2% REIMAGINE 3 (Add-on to Basal Insulin) 40 Weeks HbA1c reduction: 2.33% Weight loss: 12.0% Achieved meaningful metabolic improvements despite background insulin therapy

Generally, you will start to see improvements within two weeks, usually in terms of vomiting and/or diarrhea frequency

That lower pH is specifically what basic and hydrophobic compounds need to stay in solution

Summary scores of the Bayley-III cognitive, language and motor subscales at 6 and 12 months of age will be the primary outcome in the current study, while the assessment at 24 months will serve as secondary outcome