glutathione peroxidase location Reaction mechanism of (GPX) Glutathione peroxidase 4: a new

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M., Trojanowski, J

These enzymes are proteins that assist in shielding cells from the harmful action of oxidative stress, a process where cell components are damaged due to the presence of unstable molecules known as free radicals

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Because HepG2 cells are highly de-differentiated compared to normal hepatocytes in situ, and therefore are expected to have a less robust Met cycle and transsulfuration pathway than those found in normal liver, the GSH pool in normal liver could contain a substantially larger proportion of Met-derived S [115, 116, 118120]