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Characteristics of First-in-Human Clinical Trials Important aspects of FIH trials include the selection of a starting dose, a dose acceleration schedule, the study duration, and the administration route of the study drug

Through literature review, it is speculated that in animal models of neurodegenerative diseases, depletion of long-term nuclear receptor-assisted activator (NCOA4) in the brain can worsen the neurodegenerative disease phenotype due to the further inappropriate accumulation of free iron and resulted in oxidative stress (Quiles Del Rey and Mancias, 2019), and then induced ferroptosis in nerve cells

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Embodiments of the invention involve providing one or more HGF mimics to a subject in need thereof