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Interesting most of the literature has focused on fluid during shock resuscitation but maintenance fluid therapy and creep fluid may account for 30% of fluid balance ( Oral water may be harmful in specific subgroup such as acute heart failure, hemorrhage, or digestive ischemia

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The most recent clinical study assessing LDN in patients with inflammatory bowel disease involved 19 Ulcerative colitis patients and 28 patients affected by Crohns disease