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The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes

doi: 10.1056/NEJMoa2021713 116 StockleyRDe SoyzaAGunawardenaKPerrettJForsman-SembKEntwistleNet al

K-562 cells were transfected using the Lipofectamine 2000 Reagent (11,668019, Invitrogen) following the manufacturers instructions

In cats, vitamin B6 deficiency causes microcytic hypochromic anemia with high serum iron, convulsions, kidney lesions, failure to grow, emaciation, convulsions, anemia, oxalate nephrocalcinosis, ataxia, and, if left on the diet, seizures, and death, according to the first three studies conducted in the late 50s and early 60s (140)

When the liver is overwhelmed by environmental pollutants or poor diet, its glutathione stores can become depleted