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Coordinated pathological changes include fibrosis, stromal stiffening, and myofibroblast expansion in both compartments, which compromise joint biomechanics and serve as sources of persistent nociceptive signaling (Tang et al., 2024

It has been shown that minimal weight loss of 2-7% of body weight reduces androgen levels and improves ovulatory function

Nadadur SS, Srirama K, Mudipalli A

In RA, synovial macrophages and T cells excessively secrete TNF-, driving synovial hyperplasia and inducing IL-6 and IL-1 release, which forms an inflammatory amplification loop and leads to cartilage and bone destruction (66)

Covariate selection was performed using LASSO and backward selection on pre-selected clinical variables