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188 Concerning cervical tumor, nuclear LDHA acquired a non-canonical enzymatic activity to produce -hydroxybutyrate (-HB), which facilitated interaction between disruptor of telomeric silencing 1-like (DOT1L) and LDHA, which mediated hypermethylation of histone H3K79

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In vitro and mechanistic studies (weakest for clinical conclusions) Cell culture studies showing peptides protecting retinal cells from various insults (oxidative stress, glucose toxicity, inflammatory cytokines, hypoxia)