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Because B12 in its organic form comes from animal sources like fish, meat, eggs and dairy, vegans, vegetarians and people with nutrient deficient diets need B12 supplementation to meet minimal health requirements

39 Most studies used B12 i.m., with slightly varying dosing regimens, commonly 1000 g daily for 57 days, followed by weekly injections for another 34 weeks, and then monthly injections

Not only that, but often the form of B12 that these patients get is either cyanocobalamin or hydroxycobalamin