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Variation in the helical structure of native collagen

Sagai M, Bocci V

Science 372 , eabf1230 (2021)

Here, we see significant clustering of genes involved in pyrimidine metabolism and OxPhos, including genes in CI and CV of the ETC (Fig

In a multicenter phase II study (n = 289), niraparib exhibited clinical activity in heavily pretreated mCRPC patients with DDR defects, particularly BRCA-mutated cohorts, reinforcing its therapeutic potential in biomarker-selected populations (Smith et al., 2022)