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Furthermore, the absence of standardized formulations complicates dose uniformity and treatment reproducibility, as differences in concentration, excipients, or stability across preparations can materially influence therapeutic efficacy and safety outcomes

Third, clinical efforts should include multicenter AD biobanks to validate associations between biomarkers such as ACSL4 and GPX4 and cognitive scores, as well as combined clinical trials of ferroptosis inhibitors with anti-A monoclonal antibodies to examine therapeutic benefit in antibody-resistant patients

To overcome these obstacles, researchers have developed various delivery systems, including lipids, peptides, and polymers, for mRNA delivery both in vitro and in vivo

Mechanism of ferroptosis: a potential target for cardiovascular diseases treatment

Scientists performed an in-depth analysis of some 500 peoples immune responses over three years