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Apart from the above NPS-related phenotypes, hallucination- and delusion-like phenotypes have not been thoroughly investigated in AD mouse models due to a lack of reliable behavioral readout

however, persistent or dysregulated activation can drive neurodegeneration through inflammatory signaling, metabolic imbalance and synaptic disruption

In laboratory settings, researchers employ it to: Conduct binding and molecular interaction studies to understand how short peptides engage with proteins, DNA, and other cellular targets

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MADRS response was defined as a reduction from preinfusion score of 50% and remission was defined as a MADRS score 10