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Disulfidptosis classification of hepatocellular carcinoma reveals correlation with clinical prognosis and immune profile

Annu Rev Immunol 32:609634

Mutant #14 exhibited the highest improvement, with a 2.3-fold increase in intracellular glutathione content and a 3.2-fold increase in concentration relative to the wild-type strain (Fig

Hercynine is then processed by EgtB, a sulfoxide synthase, which catalyses iron(II)-dependant oxidative sulfurisation to conjugate -glutamylcysteine to the imidazole side chain of hercynine

As discussed earlier, the liver requires abundant glutathione to run its Phase II detoxification pathways