To minimize treatment interruptions due to adverse reactions, subsequent Phase III clinical trials may adopt a more gradual dose-escalation strategy to reduce the incidence and severity of gastrointestinal discomfort and other adverse events, thereby enhancing patient tolerance and adherence to the medication
[DOI] [PubMed] [Google Scholar] 67.Persson AK, Thun J, Xu XJ, Wiesenfeld-Hallin Z, Strm M, Devor M, et al
One of the most frequently employed animal stress models is the restraint stress model leading to severe stress gastric lesions in rats
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The traditional view of vitamin D as primarily a bone health nutrient has expanded dramatically over the past two decades