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Furthermore, it was reported that Ang IV affects both passive and conditioned avoidance response as well as motor activity

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In addition, it acts on the mitochondrial pyruvate dehydrogenase (PDH) complex to boost PDH activity, with calcium signaling and the CamKKB/AMPK pathway mediating the enhancement of glucose oxidation

Seemingly contradictory, various previous studies on tumor cell lines ( NRF2 and HO-1 upon SFN treatment in both untransformed human T-cells (Supplementary Figure 5A) and prostate cancer PC-3 cells (Supplementary Figure 5B)