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Lymphocyte infiltration of exocrine glands, autoantibody production, and an imbalance in the inflammatory cytokine network drive disease progression, ultimately resulting in glandular dysfunction and multisystem involvement

Cell Stress and Chaperones 23, 373384

Genetic variants also interact with hormone replacement therapy

The Russian clinical trial context deserves specific mention

Because these are time-dependent events, it is critical to always assess multiple time points in a pathophysiology and use parameters specific for apoptosis, while keeping in mind that many apoptosis parameters can also be modulated during a necrotic cell death