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Make a v-shape with your thumb and forefinger and hold the flesh in the outer middle section of the thigh firmly

2007 Jun;49(6):794-801 Shepherd G, Velez LI

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Seek urgent same-day assessment or call 999 for emergency care if experiencing: Severe chest pain Severe shortness of breath Fainting or collapse Acute or rapidly worsening neurological deficits (such as new limb weakness, sudden gait disturbance, or bladder/bowel dysfunction) Persistent or worsening anaemia symptoms despite treatmentincluding breathlessness, chest discomfort, palpitations, or extreme fatigueshould trigger medical review

Researchers also study TB-500 , a synthetic peptide based on the active region of the naturally occurring actin-binding protein thymosin beta-4