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Pharmacological agents, such as corticosteroids, PPAR agonists, and NF-B inhibitors, have been investigated for their ability to modulate macrophage function and polarization in COPD (115)

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The blinding of subjects and researchers was reported in four studies (Reference Hashim, Anwar and El-Fatah22,Reference Nasr9,Reference Chandil, Pande and Sen27,Reference Gayatri, Kumar and Kumar28)

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The compounded semaglutide with B12 injection makes it convenient to take both drugs together and ensures higher bioavailability than oral B12 supplements, avoiding gastrointestinal absorption issues