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The findings indicated that metformin treatment led to enhanced endometrial tolerance through the downregulation of tolerance-related miRNAs, specifically miR-1910-3p and miR-491-3p, resulting in elevated expression of endometrial tolerance markers HOXA10 and ITGB3 in patients with PCOS

Additionally, inconsistent findings across studies are due to heterogeneity in sequencing platforms, CST classification methods and analytical pipelines

Furthermore, hemolysis as an ACD is non-specific and reflects only the mechanistic damage to cells

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