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on 28 women followed for one year, the authors also demonstrated how intravesical instillation of hyaluronic acid plus chondroitin sulphate for 4 weeks and then once every 2 weeks, compared to long-term antibiotic prophylaxis using sulfamethoxazole and trimethoprim, reported similar results in terms of UTI recurrence, pain symptoms, sexual function, and quality of life [34]