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Initially, PT-141 was developed to increase skin pigmentation and tanning

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Skin lightening was noticed in a patient as a side effect of large doses of glutathione, which was given for some other disease, and then onwards, it became more popular as a skin lightening agent

Regarding restoration of BBB functionality, downregulation of P-gp could be reversed using treatment with 1,25-dihydroxyvitamin D3 as shown in a human -synuclein PFF mouse model [146]

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