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Soreness that used to linger for 48-72 hours now resolves in 24

The causes of high B12 should be investigated by a healthcare professional in addition to the individuals actual cellular B12 sufficiency levels (possibly through testing for MMA and homocysteine levels

Wamberg CH, Plovsing RR, Sandgaard NCF, Bie P

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Some studies describe occasional localized redness or mild irritation during topical research applications, while systemic toxicity has not been observed at commonly investigated research concentrations