Topiramate has been shown to be an effective and well-tolerated prophylactic medication for the treatment of migraine ( Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways
10.1038/s41401-021-00726-0 28 LiY.de HaarC.ChenM.DeuringJ.GerritsM
Superposition effects of zinc smelting atmospheric depositionon soil heavy metal polution under geochemical anomaly
N-Acetyl Cysteine (NAC) provides the rate-limiting amino acid cysteine for endogenous glutathione synthesis and has been described as a safe intervention for glutathione deficiency (Atkuri et al., 2007)
It also indicated directional differences between symptomatic patients and asymptomatic V30M carriers ( p = 0.0297), as well as between asymptomatic V30M carriers and healthy controls ( p = 0.0477
