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It is most frequently associated with the more severe G6PD Mediterranean and G6PD Cairo variants, but is also seen with lower frequency with G6PD A

The compounds require injection, and access can be limited due to cost and shortages

Nitrous oxide, a commonly used anesthetic, oxidizes and inactivates vitamin B 12 , thus inhibiting both of the vitamin B 12 -dependent enzymes, and can produce many of the clinical features of vitamin B 12 deficiency, such as megaloblastic anemia and neuropathy

Injectable peptides, including TB-500 and BPC-157, are on the World Anti-Doping Agencys list of banned substances, and theyre also banned by the U.S

They are documented for research orientation, not as a co-administration protocol