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doi: 10.1016/j.nutres.2007.12.001

Only 40% percent of patients with early stage HCC are eligible for potentially curative treatments (surgical resection, transplantation, local ablation), which prolong median survival times over 60 months ( c-Met Inhibitors So far, there are six Met inhibitors developed and they have been tested in 10 HCC clinical trials ( in vitro and in vivo trials ( Also, several clinical trials are (Table 1), including cabozanitinib, foretinib, cobazitinib, gefitinib, crizotinib, MSC2156119, AZD4547, MK2461, and INC280 ( TABLE 1 Drugs targeting HGF/c-Met in hepatocellular carcinoma patients

The dosage and frequency depend on the severity of the deficiency and the patient's medical condition