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ClarkRSBEmpeyPEBayirHRosarioBLPoloyacSMKochanekPMet alPhase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

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In cystic fibrosis, NAC provides anti-inflammatory, antioxidant, and antibiofilm effects, with emerging evidence supporting its role in non-CF bronchiectasis

In addition, the reduced glutathione: oxidized glutathione (GSH:GSSG) ratio in animals with diet-induced with NASH also highlights an imbalance between ROS and antioxidants (Iruarrizaga-Lejarreta et al., 2017)