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In these conditions, the exposure of the bacterial strains to APAP generated only very low levels of direct phase II conjugates (APAP-Glu and APAP-S) and the catechol oxidative metabolite 3-OCH 3 -APAP-Glu compared to the levels that were observed in liver models (Fig

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Assessing the effects of berberine is also difficult because the amounts and formulations of berberine used in different studies have varied widely, and most of the study participants had health problems, such as diabetes or fatty liver disease, that might have influenced the results