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Emibetuzumab (LY2875358) against c-Met and HGF and MP0250 against HGF and VEGF are two bispecific antibodies that prevent c-Met attachment to the ligand, increase the internalization, destroy c-Met molecules, and thereby reduce the signaling of the c-Met pathway [149, 174, 175]

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

Label every vial immediately upon reconstitution with both the mix date and the discard date (28 days forward) using a permanent marker directly on the vial