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Myristoylation at the N-terminus of the FSP1 protein, a lipid modification, facilitates the localization of FSP1 to the plasma membrane

(88) in an 8-week randomized double-blind, placebo-controlled trial with 80 individuals experiencing episodic migraines, discovered that the combination of omega-3 PUFAs and nano-curcumin significantly reduced migraine attack frequency and serum levels of IL-1 in a synergistic manner, though the initial significant reduction in IL-1 gene expression did not remain significant after Bonferroni corrections

A., Antoniuk-Shcheglova, I

Tang & Wang, 2010)

Moreover, in rats, supplementation with either phlorotannins, xanthohumol or quercetin (Week (W) 8-16), reversed POS-induced depressive like behavior in the FST at W12-13 [57]