A study on non-alcoholic fatty liver disease (NAFLD), GSH reduces oxidative stress and inflammation, helping to limit liver damage and fibrosis (10)
Authors Note: The structure of this letter is going to be a bit different from our usual, more narrative style at StayCurious Metabolism
1e, f was facilitated by combining two X-ray fragments found in subpockets A-C in PDB:6FP4 and PBD:6FTC via a short CH 2 CH 2 linker in a putative chimera molecule
Research Blog Guides, comparisons, and laboratory resources for peptide researchers
As outlined above, studies on non-glutathione disulfide substrates unfortunately regularly lack more detailed kinetic analyses, first, to confirm the efficient turnover of the substrate candidates and, second, to validate the dithiol mechanism