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Epitalon Research Compound: Origin and Scientific Development Epitalon emerged from a bioregulator research program that began in the 1970s, built on the premise that specific organs produce short peptide sequences capable of regulating gene expression in a tissue-specific, age-dependent manner

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A particular relationship was established with the NO-system, and the advantage of the BPC 157 over the corresponding standard agents (i.e., corticosteroids, sulfasalazine, H2 blockers, anticholinergics, and proton pump inhibitors) which showed only weak, if any, effect on these fistulas closing (Klicek et al., 2008