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In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Lemley C.O., Meyer A.M., Camacho L.E., Neville T.L., Newman D.J., Caton J.S., Vonnahme K.A