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Additionally, curcumin has anti-inflammatory and immunomodulatory effects on UC, which is related to its ability to regulate the function of DCs and Treg/Th cells [265, 266, 268]

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Hepato-protectant (NAC) and ER stress inhibitor (4-PBA) significantly downregulated ER stress markers in the liver compared to the MTX group, as depicted in Figures 6AE